Dr. Jennifer Ashton profiles Dr. Anthony Fauci as he prepares to leave the NIH after 54 years of service, emphasizing that he views the transition not as retirement but as a new chapter. Fauci attributes his vitality at nearly 82 to healthy habits, lifelong exercise, moderation in food and alcohol, good genetics, and—most importantly—a strong sense of purpose. Despite maintaining demanding workdays, his wife, Dr. Christine Grady, helps ensure he eats, hydrates, and rests. Fauci looks forward to spending more time with family, becoming a grandfather, reading, watching baseball, traveling, and continuing to make an impact beyond his NIH role.