Dr. Anthony Fauci reflects on ending his 54-year career at the NIH while emphasizing that he is not retiring, but beginning a new chapter. In an interview with Dr. Jennifer Ashton, he attributes his energy and longevity at nearly 82 to exercise, moderation in eating and drinking, good genetics, and—above all—a strong sense of purpose. Fauci maintains an intense schedule, wakes at 5 a.m., and has support from his wife, Dr. Christine Grady, who helped ensure he ate, hydrated, and rested during the early COVID-19 crisis. Looking ahead, he hopes to spend more time reading, watching sports, traveling, and being with his family, including his soon-to-arrive grandchild.