Dr. Anthony Fauci reflects on leaving the NIH after 54 years of service, emphasizing that he is not retiring but beginning a new chapter. In an interview with Dr. Jennifer Ashton, he credits his energy and longevity—despite being nearly 82—to regular exercise, moderation in eating and drinking, good genetics, and, above all, a strong sense of purpose. His wife, Dr. Christine Grady, describes helping him maintain meals, hydration, and sleep during the intense early COVID-19 period. Fauci also looks forward to spending more time with family, becoming a grandfather, traveling, reading, watching baseball, and exploring future ways to communicate with the public.